Marshall Henderson and Demarco Cox each added 15 for Mississippi, which improved to 5-0 this season. Cox also grabbed 13 rebounds.
The Rebels will play the winner of the Penn State and St. John's game in the tourney's championship game Saturday afternoon.
Ole Miss took control with an 18-7 run spanning 6:08 in the first half. Henderson started the run with consecutive three pointers, and he later added a third made three.
Solomon Poole led Georgia Tech with 24 points. Robert Carter Jr. had 11 points and 13 rebounds. Trae Golden and Marcus Georges-Hunt chipped in with 10 points apiece.
Georgia Tech will play in the early season tournament's consolation game tomorrow. The Yellow Jackets fell to 5-2.
Henderson shot 5-of-15 from the field, including 4-for-14 from the 3-point line, in 27 minutes. At the half, the Rebels led 35-21 on 40.6 percent shooting from the field, including 46.2 percent from three.
By comparison, Georgia Tech only made 7 of 34 shots from the field in the first half, and were 1 for 10 from three point range. The Yellow Jackets shooting improved in the second half, as they made 16 of 29 from the field and 6 of 10 from three.
Mississippi's lead grew to as much as 21 points in the second half. The Rebels finished the game shooting 43.5 percent from the field.
Despite the loss, Georgia Tech leads the all-time series 11-9. Friday afternoon's game marked the first time the programs met since Jan. 11, 1964.